FEV1 Minimum Important Difference versus Minimal Detectable Difference? In Search of the Unicorn
نویسندگان
چکیده
منابع مشابه
How important is a minimal difference?
C linical trials typically report the mean effect of interventions with an indication of the variability or 95% confidence interval signifying whether an intervention leads to statistically significant effects. A statistical difference does not necessarily inform clinicians or policymakers as to whether patients will perceive these effects as a benefit or whether the effect is of any clinical r...
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Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surger...
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OBJECTIVE To estimate the minimum clinically important difference (MCID) for several pain measures obtained from the Brief Pain Inventory (BPI) for patients with fibromyalgia. METHODS Data were pooled across 12-week treatment periods from 4 randomized, double-blind, placebo-controlled studies designed to evaluate the safety and efficacy of duloxetine for the treatment of fibromyalgia. Each st...
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BACKGROUND This study was conducted to establish the minimal detectable change (MDC) and clinically important differences (CIDs) of the physical category of the Stroke-Specific Quality of Life Scale in patients with stroke. METHODS MDC and CIDs scores were calculated from the data of 74 participants enrolled in randomized controlled trials investigating the effects of two rehabilitation progr...
متن کاملStatistical Development on Determining the Minimum Clinically Important Difference
In medical research, the concept of minimum clinically important difference (MCID) has gained its popularity among clinical practitioners and health policy markers. Over the past 20 years, intensive research has been conducted to explore how clinical significance could be interpreted from the patient reported outcomes (PROs) by using MCID. This article aims to provide a review on the statistica...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2021
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.202012-4322le